PROSPECTIVE RANDOMIZED COMPARATIVE STUDY BETWEEN EBRT ALONE AND EBRT WITH ILRT BOOST IN LOCALLY ADVANCED UNRESECTABLE ESOPHAGEAL CANCER - TERTIARY RURAL INDIAN CANCER CENTER EXPERIENCE

Prospective randomized comparative study between EBRT alone and EBRT with ILRT boost in locally advanced unresectable esophageal cancer - Tertiary rural Indian cancer center experience

Background: Local recurrence within the gross tumor volume following a conventional radiation dose of 50 Gy is a major hurdle in achieving a better prognosis for esophageal carcinoma.Consequently, there remains a lack of consensus globally regarding the optimal dose for definitive concurrent chemoradiotherapy.Certain studies propose that radiation

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Stability in skipping gaits

As an alternative to walking and running, humans are able to skip.However, adult humans avoid it.This fact seems to be related to the higher energetic costs associated with skipping.Still, children, some birds, lemurs and lizards use skipping gaits during daily locomotion.We combined experimental data on humans with numerical simulations to test wh

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Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Summary: A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis.Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation.However, it remains unclear how stem cells metabolically adapt.In this study, we show that pharmacological inhibition of

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THE POSSIBLE CONFIDENTIALITY: THE PUBLIC ADMINISTRATION AS PARTY IN THE ALTERNATIVE DISPUTE RESOLUTION MECHANISM

This article debates the tension that exists between confidentiality, usual in ADRs, and the publicity principle, that rules the Public Administration in Brazil.As a solution points that the parameter mahotsav norita saree of confidentiality when Public Administration is a party must be the preservation of accountability of the involved agencies, w

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